A roadmap of priority evidence gaps for the co-implementation of malaria vaccines and perennial malaria chemoprevention

Effective malaria control requires combining interventions like malaria vaccines and perennial malaria chemoprevention (PMC). However, despite their joint introduction in some programs, empirical evidence on the impact and optimal co-implementation of these two strategies is scarce. A 2023 stakeholder meeting identified critical policy, operational, and research gaps. This led to a strategic roadmap outlining four priority areas: supporting global and national policy, enhancing implementation research, conducting clinical studies, and developing modeling tools. This roadmap aims to provide practical guidance and robust evidence for designing, optimizing, and scaling up co-implementation, including assessing cost-effectiveness and optimal schedules, ultimately ensuring the most impactful use of resources for childhood malaria prevention.